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The upper respiratory system includes the nose, mouth, sinuses, and throat. When you have an upper respiratory infection, you may feel uncomfortable, have a stuffy nose, and sound very congested. Other symptoms of an upper respiratory infection include: Facial pain or pressure, a runny or stuffy nose, which may lead to blockage of the nasal passages and cause you to breathe through your mouth, a sore throat, irritability, restlessness, poor appetite, and decreased activity level.